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By univariate analysis, the duration of use (OR 0.85, 95% CI 0.780.93) and a very strong level of dependence ( OR 0.53, 95% CI 0.320.87) were inversely associated with the willingness to quit

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Smoking basically brings you back to the baseline level you should have been at if youd never smoked in the first place. One key consequence of this is that smoking often has a profound impact on mental health, because youre essentially in constant withdrawal if you dont have a cigarette in your hand

Dopamines activity in the mesolimbic dopaminergic system is the basis for the reward learning, motivational, and reinforcing effects of tobacco (61)

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