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Michael Bloomberg, a fierce detractor of e-cigarettes, warns without any clinical evidence that adolescent vapers risk IQ losses of up to 15 points for the rest of [their] life. The CDC states that nicotine can harm brain development, which continues until about age 25. Prominent anti-smoking organizations and the surgeon general also forecast bad outcomes

Simmons as B.R., Nick's boss Robert Duvall as the Captain, founder of the Academy for Tobacco Studies Kim Dickens as Jill Naylor, Nick's ex-wife Connie Ray as Pearl Todd Louiso as Ron Goode Marianne Muellerleile as Joey's school teacher Dennis Miller as himself Melora Hardin as Interviewer Daniel Travis as Brad, Jill's current partner Director Jason Reitman asked many of his prospective actors and actresses to be in the film by writing each of them a personal letter