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Research estimated that the fertility of smoking women was 28% lower than of non-smokers
doi: 10.1016/j.chroma.2010.10.018
In fact, UVR-activated p53 promotes apoptosis through transcriptional activation of pro-apoptotic genes, such as p53-upregulated modulator of apoptosis ( PUMA) [41] and phorbol-12-myristate-13-acetate-induced protein 1 ( PMAIP1 ) (encoding NOXA protein) [41], which bind and inhibit the pro-survival BCL-2 proteins, such as BCL-2, BCL-XL, and Myeloid Cell Leukemia 1 (MCL-1) [42], thereby unleashing the pro-apoptotic effectors BCL-2-associated X protein (BAX), BCL-2 Antagonist/Killer (BAK), and Bcl-2-antagonist of cell death (BAD)
That includes the actual chemical exposure that users receive compared with traditional smokers' intake
The P72R polymorphism of p53 predisposes to obesity and metabolic dysfunction
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