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These potential confounders were selected based on the literature (i.e., based on their known/hypothetic correlations with both the exposures [i.e., maternal smoking] and outcomes [i.e., congenital anomalies]) as well as the information that was available on the birth certificate

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Withdrawal affects everyone differently based on what substance you used, how long you used it, how much you typically used, your overall health, and whether you used multiple substances