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Increasing use of ECs may have contributed to this change, though it is difficult to disentangle the impacts of ECs from those of other interventions such as annual tobacco tax increases and the implementation of standardised packs and enhanced health warnings in 2018

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Animal studies indicate the anti-inflammatory effects of short-term nicotine exposure, while its long-term effects can cause inflammation and fibrosis [190]

Summary Keywords adolescents, e-cigarettes, nicotine addiction, prevention strategies, public health, vaping Citation Fainardi V, Barbetta E, Petz M, Rizzo L, Ruberti F and Esposito S (2026) The new nicotine epidemic: understanding the systemic harms of e-cigarettes in the adolescent population

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