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In dysplastic epithelium, cells may become vertically orientated rather than becoming flat towards the surface

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Cereb Cortex 29(12):521733 Ekblad MO, Ngum P, Merisaari H, Saunavaara V, Parkkola R, Setnen S (2022) Maternal smoking during pregnancy negatively affects brain volumes proportional to intracranial volume in adolescents born very preterm

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Across all nations and regions, average per-capita cigarette consumption was above the national average for Great Britain among those from less advantaged social grades (highest in the East of England, 935 cigarettes per year) and below the national average among those who were more advantaged (lowest in London, 292 cigarettes per year)