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Data extraction and quality assessment For included studies, data were extracted including author, year, country, aim, study design, sample size, participants and relevant findings such as effect sizes and nature of impact on health outcomes

Tolerance, as defined by either of the following: A need for markedly increased amounts of tobacco to achieve the desired effect

The oral LD 50 (mouse) of resorcinol and phenol are 302 mg/kg and 301 mg/kg, respectively

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