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In another p53-null HCC line, the cell growth of Hep3B cells can be inhibited by melatonin (a hormone for regulation of circadian rhythms), which can promote the expression of several proapoptotic target genes (p21 and BAX) of p53 146
Walczak-Jedrzejowska R, Wolski JK, Slowikowska-Hilczer J (2013) The role of oxidative stress and antioxidants in male fertility
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Moreover, it was reported that HBx protein-mediated p53 inactivation was found throughout the whole process of the natural history of HBV infection, which can be detected in chronic hepatitis B (CHB), cirrhosis, and HCC, and might contribute to disease development
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