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pig and human share virus -pigs provides a mixing pot able to be infected by the avian virus, thus allowing passage to humans -glycoprotein spikes of two types, H and N, are capable of mix and match causing antigenic shift -16 H types and 9 N types -H5 stands for the fifth of several known types of the protein hemagglutinin -N1 stands for the first of several known types of the protein neuraminidase Spanish Flu Pandemic -it is thought to be one of the most deadly pandemics in world history -The Spanish flu was an unusually severe and deadly strain of avian influenza that killed some 50 to 100 million people worldwide over about a year in 1918 and 1919

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