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doi:10.1542/peds.2017-3594 Kulik MC, Lisha NE, Glantz SA

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One of the possible causes is that nicotine in tobacco smoke leads to oxidative stress and hence insufficient oxygen is supplied to the skin, which results in tissue ischemia and blood vessel occlusion

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Higher taxes on cigarettes were another important factor in helping the U.S

Monitors should be sufficiently independent from the leaf production component of business operations and from local suppliers