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Our operational definition of MI and stroke occurrence could also have been subject to misclassification

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On the other hand, contradictory results have also been described, with regular users of ENDS exhibiting lower endothelial-dependent vascular dilation and diminished nitric oxide production when compared to non-users, with concomitant increased inflammatory biomarkers [125]

The FDA has responded to this increase with proposed changes to regulations of ENDS (Cullen et al., 2018)

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