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Key symptoms include severe confusion, vomiting, seizures, and slow or irregular breathing (less than eight breaths per minute)
First, the bias covariates used, although carefully extracted and evaluated, were based on observable study characteristics and thus may not fully capture unobserved characteristics such as study quality or context, which might be major sources of bias

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This is hugely important as the former smoker develops new responses to any habitual triggers to smoke over the first few weeks of being a happy non-smoker

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