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LC separation was performed on a Waters Acquity UPLC BEH 1.7 m 2.1 50 mm column using a 0.6-ml/minute gradient of A/B 95/5 to 15/85 in 4 minutes followed by washing and reconditioning the column

We found that inhibiting the expression or function of SREBP2 and HMGCR reduced intracellular cholesterol levels (Figure 3CF), thereby inhibiting CSE-induced secretion of inflammatory factors IL6 and IL8 in airway epithelial cells (Figure 3D, E and G)

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