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But according to one recent study by researchers at Austria's Karl-Franzens University Graz in the medical journal Archives of Toxicology , a dose of more than 0.5 g liquidized nicotine could harm an adult

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One animal study demonstrated that PNE increases expression levels of cholesterol side-chain cleavage enzyme (P450scc) and adrenal steroid acute regulatory protein (StAR) in pregnant rats and reduces the levels of 11-hydroxysteroid dehydrogenase-2 (11-HSD-2) which is responsible for the inactivation of mother-derived GC [46]