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Effect of Toxic Gases on Intestinal Microbiota The main toxic gases of tobacco smoke, including carbon dioxide, carbon monoxide (CO), hydrogen sulfide (H 2 S), ammonia, hydrogen, and nitrogen oxides (NO x ), are inhaled into lung and entered into blood through alveolar exchange, which affects the O 2 transport, decreases the pH of blood, and induces systemic inflammation and diseases ( 2 transport and results in systemic hypoxia ( Hydrogen sulfide as another major constituent of cigarette smoke causes both pro-inflammatory and anti-inflammatory responses, even induce metabolic disorders in a few vertebrates ( 2 S donors (diallyl disulfide) promotes biofilm formation and reduces growth of planktonic bacteria ( 2 S (0, 5, 10, and 15 mg/m 3 ) for 28 days, the abundance of Firmicutes and Proteobacteria were increased and the abundance of Bacteroides were decreased in the weaning pigs ( Effect of Heavy Metals on Intestinal Microbiota Cigarette smoke contains many heavy metals (such as cadmium, arsenic, lead, chromium, iron, mercury, nickel, and vanadium), which are inhaled into the lungs as aerosol particles or free in a gaseous state ( Barnesiella , and Clostridioides XIVb ( Potential Mechanisms of Organ Cross-Talk Potential Mechanisms of the Lung-Gut Axis Cigarette smoking is the primary causes of COPD and about 80% present patients with COPD are the former or present smokers (Figure 1)