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[2] However, these laws kept changing throughout the 1950s, with Maryland repealing its age restrictions

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The tobacco company RJ Reynolds patented nicotine salts to increase the nicotine content of products but prevent what would otherwise cause more intense throat irritation if it were freebase nicotine of such concentration

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Second, systematic misclassification can interact with sociodemographic or clinical correlates of both reporting and outcomes (for example, stigma, socioeconomic status, or later maternal smoking cessation), producing biased or confounded inferences about who is at risk