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While early research provided a strong foundation, it was largely exploratory and not designed for risk assessment applications

Although they eliminate some combustion-derived toxins, they still deliver harmful substances capable of inducing oxidative stress, mitochondrial dysfunction, inflammation, and hepatocellular injury

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However, its potential regulatory mechanisms need to be further studied

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"Peace Navy" (the colour of the redesigned cigarette packaging) began being used as a design term, and sales for Peace tripled after the design renewal