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A 2023 review in Frontiers in Pharmacology noted that while the ECS is a promising therapeutic target for inflammatory GI diseases, clinical data remains limited and inconsistent

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2018 September;67(9):560-561,563-564 History of smoking tobacco and cannabis Dyspnea Chest tightness THE CASE A 24-year-old man with a history of smoking tobacco presented to the hospital with acute-onset chest tightness and dyspnea shortly after smoking cannabis

They cite tobacco smoke as one of the main culprits, saying that it has a lethal mix of thousands of chemicals, 70 of which have been shown to cause cancer

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