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IL-8 is a cytokine that is involved in neutrophil recruitment/migration into the lungs and interleukin secretion was significantly greater after LC than Kentucky cigarette exposure, suggesting that in addition to being more toxic, that LCs may also induce more inflammation and place LC smokers at greater risk from chronic neutrophilia 17,27

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For LMICs, median maximal market share was 60.0% (IQR: 46.075.0) in 2011 and 57.0% (IQR: 43.071.0) in 2020 (Supplementary file Table 1)
