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Extracellular signal-regulated kinases and c-Jun N-terminal Kinase (JNK) promote the phosphorylation and activation of the activating protein-1 transcription factor (AP-1) components, which are primarily proteins from the Fos and Jun families

Histone acetylation occurs at different lysine sites, among which H4K12 can participate in cell aging 32

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MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics

1986 Carcinogenesis 7 : 759766 Greenblatt MS, Bennett WP, Hollstein M, Harris CC

Increased p53 can bind to the Plzf promoter and negatively regulate Plzf , leading to a reduction in Plzf expression and the number of Plzf + SSCs in mouse testes, resulting in a decrease in male fertility ( TP53 transcription and promoting the ubiquitination and degradation of p53 in several cell lines ( Csnk1a1 , the gene encoded Casein kinase I isoform alpha (CKI-), knockout accelerated nuclear p53 protein expression by disrupting Mdm2-mediated p53 ubiquitination in mouse spermatogonia