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Indeed, the major compound of nicotine is mostly used in smoking cessation therapy in a variety of dosage forms for different routes of administration such as oral, sublingual, transdermal, nasal, or inhaler

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Surgeon General , CDC , FDA , AMA, World Health Organization , and the National Institute on Drug Abuse , classifies nicotine as the primary addictive compound in tobacco products.[7] Clinical reports have documented patients who, despite never smoking, developed severe dependence on nicotine gum

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