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Smoking-Related Molecular Mechanisms At present, the pathogenesis of AAA is mainly attributed to inflammatory cell infiltration, the destruction of elastin and collagen in the media and adventitia, biological changes in smooth muscle cells and angiogenesis (180, 181)

doi:10.1016/j.anpedi.2011.12.008 21

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Immunosuppression, such as that in OTRs, has been connected to increased incidence of a variety of skin cancer types 20