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DNA topoisomerases in cancer therapy

Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one derivative as a potent and selective dual TYK2/JAK1 inhibitor for the treatment of inflammatory bowel disease

doi: 10.1016/j.carbpol.2019.115659

With low GSH levels being associated with many chronic pro-inflammatory conditions, such as cardiovascular, renal, and hepatic disease, metabolic syndrome, as well as neurodegenerative conditions and autoimmune disease (Hristov BD, 2022)

j-k , Serum tGSH (no tumor vs

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