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However, when challenging G6PD def erythrocytes with the oxidant diamide, GSH is depleted, and erythrocyte metabolism shifts towards GSH biosynthesis

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[DOI] [PubMed] [Google Scholar] 8.Vitale M., Gomez-Estaca J., Chung J., Chua S.C., Pampanin D.M

These pulsatile as well as nychthemeral secretory patterns are pre-eminent physiological features of healthy GH release and are critical to physiological regulation and long-term activation of the GH neuroendocrine axis

This dual capability positions melatonin as a robust non-enzymatic antioxidant, functioning both intra- and extracellularly [93]