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Psychiatric side-effects of medications: recent developments

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PLoS One 5 (8), e12249

A clinical laboratory in the United States that uses radio-immunoassays defines high titers in stiff-person syndrome and related GAD-spectrum autoimmune disorders as greater than 20.0 nmol/L (1000 times above the normal, 0.02 nmol/L) with 93% positivity

Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]

113,114 However, persistent induction of macrophage M1 phenotype polarization aggravates the inflammatory response through the secretion of IFN-, 115 leading to cardiomyocyte apoptosis and ECM degradation