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Except for pseudomyxoma peritonei, in which data revealing notable CRP increases arise mostly from case reports during the diagnosis of the condition, a study concluded that CRP kinetics and concentrations are decisive predictive markers of early and late postoperative complications after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis, and another study found that elevated CRP concentrations are correlated with poor survival in patients suffering from peritoneal carcinomatosis of colorectal origin

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doi:10.1111/jsr.13743

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Melanocytic activation is characterized by hyperpigmentation of the matrix epithelium, secondary to activation of the suprabasal layer melanocytes in the proximal matrix and basal layer melanocytes in the distal matrix, without an increase in the number of melanocytes [1] (Fig