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Journal Of Neurochemistry , 125 , 897908 Zador, F., Joca, S., Nagy-Grocz, G., Dvoracsko, S., Szucs, E., Tomboly, C., Benyhe, S., & Vecsei, L

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Neurological disease Asparagine synthesis disorder (ASD) is a newly discovered neurological disorder associated with mutations in the ASNS gene on chromosome 7q2

Following lead identification, efficacy and PK should be demonstrated using the intended clinical route of dosing, and toxicology tests should also be performed using the intended clinical route of dosing, except in rare cases where dosing is target-specific and systemic exposures are negligible

In the fifth step of the mechanism, which is the third chemical step, Tyr9 deprotonates the glutathione thiol, restoring the active site of the enzyme to the initial state

Several other studies have highlighted the effectiveness of this strategy to enhance viral clearance