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[] In addition to TGM2 and ASK1, glutamine has protective effects on the kidneys through the activation of heat shock protein-70 (HSP-70), which regulates the mitigation of inflammatory responses and neutrophil infiltration in the kidneys

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Furthermore, increased HSP90 and the decreased GPX4 levels were detected in subcutaneous xenograft tumors after Tim-AIII administration, which further confirmed HSP90 and GPX4 were the main players involved in the anticancer effects triggered by Tim-AIII

When nutrition is sufficient, mTOR inhibits ULK1-2, thereby suppressing autophagy