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High fever with chill Increasing redness, warmth, swelling, or pain at the injection site A pus-like discharge Red streaks spreading outward from the injection site Common Reasons for Needing an IM Injection Self-administered IM injections may be used for different reasons, including assisted fertility treatments, gender-affirming hormone therapy, vitamin B12 supplementation, and some disease-modifying treatments for autoimmune diseases like rheumatoid arthritis

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