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Conversely, the methylation frequency of HTERT is associated with the aging process and is significantly higher in AD patients compared to elderly controls, potentially reflecting AD-related telomeric and immune dysfunctions (63)

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Collectively, these regulatory mechanisms provide critical insights and potential targets for the study of tumor metabolic reprogramming and targeted therapy development

In another study, a research investigation regarding the influence of the miR-217/SIRT1 axis on EMT in chronic pancreatitis and pancreas malignancy, it was found that miR-217 displayed a reverse association with its specific target SIRT1

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Furthermore, hydrogen water can support enzymatic antioxidant activity by reducing overall oxidative burden, preserving cofactor availability, and even upregulating enzyme expression through hormetic mechanisms