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However, further studies are needed to determine whether this therapeutic approach would be effective in the treatment of chronic conditions such as MASLD [199]

NRF2 and cancer NRF2 is frequently mutated in many types of cancers, with the mutations clustered around the DLG (43 %) and ETGE (57 %) motifs, which are the two critical KEAP1 interaction domains [95]

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References Bousso, P

NF-kappaB, AP-1, Zinc-deficiency and aging

Future research should further clarify the cell-specific and stage-specific functions of HIF-1 in osteomyelitis to enable precise therapeutic targeting