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88 Kimura et al

Source: Paywalled Paper: Ergothioneine as a potential geroprotector: Targeting molecular hallmarks of ageing and age-related diseases Institution: Department of Pharmacology (School of Pharmacy) and Department of Radiology (Shengjing Hospital), China Medical University, Shenyang, China

Caspase Activity was assessed by Clontechs assy while 10 ug/ml of TNF-alpha was used to induce apoptosis

Each process was scored using AddModuleScore function in Seurat package

Synergistic Effects: Combined Pathway Modulation When used together, BPC-157 and TB-500 demonstrate complementary actions[6]: Inflammation control : Both peptides reduce excessive inflammatory responses while preserving necessary healing inflammation Vascular support : BPC-157s VEGFR2 activation combined with TB-500s angiogenic effects provide robust blood vessel formation Cellular recruitment : BPC-157s FAK/paxillin signaling paired with TB-500s actin-mediated migration accelerates cell arrival at injury sites Structural remodeling : TB-500s cytoskeletal organization complemented by BPC-157s collagen formation improves tissue integrity Key Mechanistic Insight: The BPC-157 + TB-500 combination addresses tissue repair from multiple angles local cytoprotection and angiogenesis (BPC-157) paired with systemic cellular migration and structural remodeling (TB-500)

This work was also supported by grants from Key Laboratory of Tropical Marine Ecosystem and Bioresource, Ministry of Natural Resources (2021ZD01 to M.L.)