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It is a major health issue that exponentially reduces health and economy and also causes serious morbidity and mortality across the globe

Plasma LC levels were shown to be lower in obese rats fed a HFD for a year, and this was concomitant to lower expression of hepatic regulatory LC genes

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In 2013, Phongmitr et al

For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)

J., Wong, M