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[DOI] [PubMed] [Google Scholar] Berthold ECKamble SHRaju KSKuntz MASenetra ASMottinelli MLen FRestrepo LFPatel AHo NP, et al

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They may arrange blood tests to evaluate: Inflammatory markers (ESR, CRP) to detect active inflammation Rheumatoid factor and anti-CCP antibodies if inflammatory arthritis is suspected Full blood count to assess haematological response to B12 treatment Thyroid function tests , as thyroid disorders commonly coexist with B12 deficiency Note that serum B12 levels are not typically measured to assess treatment adequacy once replacement therapy has begun, as they may not reliably reflect tissue stores

This is mechanism evidence, not outcome evidence

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Low maternal B12 status is associated with offspring insulin resistance but B12 or folate supplementation does not alter that risk