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Available online: [DOI] [PMC free article] [PubMed] [Google Scholar] 22.Swami O., Dongre Y

At the end of this 7-day labelling period ( t = 0 h), samples were collected to verify complete incorporation of the heavy label into cellular proteins

Phosphorylation of Ser375 persisted long after removal of morphine from cells but was readily reversible using the strongly internalizing agonist DAMGO

Various PKC isoforms (PKC, II, , ) activated by phorbol 12-myristate 13-acetate (PMA) trigger MOR phosphorylation at S363 and T370 but those kinases are not recruited upon DAMGO stimulation (Doll et al., 2011

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Covers: biochemistry of amylin, receptor biology (CTR + RAMP complex), physiological functions, clinical applications, the Pramlintide experience, perspectives for long-acting analogs
