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however, it was comparable to that of SeGST [23] as it was within the normal range (below 1 mM), which is similar to that of many mammalian GSTs [38]

Furthermore, GSTs are additionally identified as regulators of cellular signaling pathways, thereby influencing cell proliferation or apoptosis ( in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds

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Kent M, Rice D, Flores R

Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC- /akt pathway in female golden hamster: involvement of altered AANAT and Bmal1 rhythm