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Controls were untreated, and showing 100% growth, while tests measured percentage decrease in bacterial growth with respect to this control
Furthermore, we showed that rv 1127c is more susceptible to bedaquiline (BDQ) than wild-type (WT) Mtb (Mackenzie et al, 2020), and therefore drugs targeting Rv1127c may synergise with BDQ, which is the backbone of the oral, shortened treatments for antibiotic-resistant TB

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Wu W, Wang P, Cheng JX, Xu XM

doi: 10.1186/s12967-020-02455-0 9 JasonLARichmanJARademakerAWJordanKMPlioplysAVTaylorRRet al

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