is selenium part of the glutathione peroxidase enzyme system Selenoprotein 4: From Molecular Mechanisms to Novel Therapeutic Opportunities Elemental - Selenium and Vitamin

Saotome, T

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H.ChenY.WangN

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In addition, factors including ageing, poor diet, smoking, excessive alcohol consumption, chronic disease, and certain medications may disrupt normal methylation patterns

The presence of two significant elements in the regulatory region of the MT-1 and MT-2 genes, namely, the TATA box (serving as the core promoter element) and multiple cis-acting response elements, including metal-responsive elements (MREs) and antioxidant-responsive elements (AREs), drives their expression [32]