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In cancer patients receiving radiotherapy, studies have shown that carnitine homeostasis is negatively affected and especially in combination with the toxic side effects chemotherapy, the L-carnitine levels and homeostasis could be further compromised [21]

These observations were confirmed in an exhaustive screening of HDL apolipoproteins allowed us to demonstrate that apoC1 was the main contributor to the inhibition of CETP when present as a component of HDL [95]
Genetic risk factors for NAFLD Genomewide association studies identified a mutation in the ATGL homologue PNPLA3 (also known as adiponutrin) as a risk factor for hepatic steatosis prevalence and progression 166169

En ellos se ha observado un incremento de la tolerancia al ejercicio en pacientes con angina de esfuerzo 26 , mejora en la sintomatologa 27 en pacientes con infarto de miocardio reciente, mejora de parmetros hemodinmicos y otros (patrn lipdico), atenuacin de la dilatacin del ventrculo izquierdo en el postinfarto 28 e incluso disminucin de la mortalidad 29

In this article, we will make a short review of LDL metabolism, discuss the discordance between LDL-C and LDL-P, outline the atherogenic mechanisms of action of LDL by focusing on sdLDL and ox-LDL, summarize the methods used for measurement of LDL subclasses, and conclude the advances in LDL-lowering therapies using statins and PCSK9i
