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Moreover, ionizing radiation can induce pyroptosis in cancer cells expressing the GSDME protein, such as those found in lung, liver, breast, and glioma cancers [189]

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While the FDA's decision has no bearing on access in other countries, it does build momentum for other regulatory authorities to approve the drug, says Carmen Prez Casas , senior strategy lead at Unitaid, a United Nations agency that helps reduce the cost of treatments for HIV/AIDS, TB and malaria

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