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It is more likely that endotoxins can either be absorbed directly through the enterocyte apical cell membrane or by a receptor-mediated transcytosis followed by exocytosis at the basolateral epithelial cell membrane [47, 49,50,51] (Fig

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In addition, the colonic injury and inflammation induced by dextran sodium sulfate are more severe in the JAM-A knockout mice than in wild type mice.34 4