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It can be seen that GPX5 is essential in regulating oxidative stress damage in the epididymis and protecting sperm maturation, which is of great significance in maintaining the reproductive ability of mammals

It has also been found to improve the absorption of iron in patients with iron deficiency anemia, helping to address this common nutritional disorder

In contrast, APAP-CYS was capable to induce only a mild impairment in HK-2 cells and APAP did not induce any significant changes in treated cells

J Altern Complement Med 3: 327-336

Finally, we suggest that vitamin C, as a readily available and safe agent, could be used for the treatment and prevention of the neurodegenerative diseases in CNS

In the absence of GPX4, lipid peroxidation via 12/15-lipoxygenase leads to activation of the apoptosis-inducing factor (AIF) to induce cell death