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Bevacizumab, a monoclonal antibody against VEGF, has been shown to be effective in preventing tumor progression and is one of the few pharmaceutical treatment options available for the treatment of schwannomas [41,42,43]

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Alterations in the normal activities of SM-cycle enzymes have been linked to many central nervous system-related pathologies such as Alzheimers, Parkinsons, ischemia/hypoxia, depression, schizophrenia or Niemann-Pick diseases 19 .Specific SL functions have often been characterized in cells with decreased amounts of SL, using either SL-degrading enzymes (e.g

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