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To summarize, mounting evidence suggests that S- glutathionylation plays an important role in the regulation of several primary metabolism enzymes, and could impact carbon metabolism during conditions inducing oxidative stress

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Gojkovic S., Krezic I., Vranes H., Zizek H., Drmic D., Batelja Vuletic L., Milavic M., Sikiric S., Stilinovic I., Simeon P., et al

Interestingly, while we did not observe any morphological changes in the WAT of young mice nor in 1-year old mice after 3 weeks of doxycycline, we did observe decreased adipocyte size upon Nfs1 knockdown after 7 weeks of doxycycline (Fig 4K)