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Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase

The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction (SAVOR-TIMI) 53 trial assessed the impact of saxagliptin on cardiovascular outcomes and reported an increase in rates of hospitalisation for HF with no impact on ischaemic events.85 Further clinical trials have been conducted, reporting no increased risk of HF or other cardiac outcomes,86 however, these trials still report no improvement

King CK

Neurotoxicity has been linked to magnetic resonance imaging contrast agents in rodent models and case reports (Rogosnitzky and Branch, 2016)

For instance, during oxidative stress, certain Prevotella species can promote intestinal mucus barrier dysfunction and inflammation (Tett et al., 2021), and some, such as melanin-producing Prevotella , may act as opportunistic pathogens

Neurosci Lett (2017) 636:12733.10.1016/j.neulet.2016.10.054 32 JornayvazFRShulmanGI
