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First-generation copper chelators, including the 8-hydroxyquinoline derivative CQ, have shown efficacy in preclinical models by redistributing metal ions within A plaques, reducing A-induced neurotoxicity and improving cognitive performance in transgenic mouse models of AD (240)

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Proline biosynthesis is a vent for TGFinduced mitochondrial redox stress

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The chromatin was incubated for 1 hour at 4 C on a rotating wheel with 20 l blocked protein G sepharose beads