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The pruritus associated with cirrhosis exacts a toll on quality of life, exacerbates sleep disturbances and mental health disorders including suicidal ideation, and serves as a primary driver of recurrent outpatient consultations

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It can be seen that visual staining intensity aligned with the quantitative values presented in Figures 4 and 5, and that 5xFAD mice treated with intranasal GHK-Cu had reduced levels of MCP-1 similar to wild type controls

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