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Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus

used intranasal (IN) administration of mourinic micrometer-sized iron oxide (MPIO)-labeled MSCs in a rat model created by intraperitoneal (IP) administration of rotenone

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Among the clear clinical benefits are the improvement of differential diagnosis, stratification of prognosis, and monitoring of disease progression, as well as the guidance of interventions targeting modifiable factors (Alcolea et al., 2023

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Clinically, LOAD begins with episodic memory decline and gradually advances to involve executive dysfunction (Kelly et al., 2020) language disturbances (Paolini Paoletti et al., 2021) and impaired daily living (Guo et al., 2022)
