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[383] showed that ferulic acid administered orally one hour after the UC induction and during five days at 20, 40, and 60 mg/kg doses ameliorated UC through the inhibition of the LPS-TLR4-NF-B and NF-B-INOS-NO signaling pathways

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If intranasal bioavailability is 10% relative to subcutaneous, a 10-fold higher nasal dose would be needed to match exposure, but ceiling effects, tolerability, and mucosal volume limits complicate this further

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One of the oncogenic effectors associated with Cdc42 is PI3K, and the Akt signaling pathway activated by the EGFR-Cdc42 is significantly linked to tumor recurrence and resistance [43, 44]

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