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negative 2/10 HPF correlated with metastases (P=0.008) [34]

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Peroxisome 2,4-dienyl-CoA reductase 2 (DECR2) is the key enzyme in pFAO, and overexpression of DECR2 in PCa can enhance pFAO

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Core pathway: Progesterone 17-hydroxyprogesterone 11-deoxycortisol Cortisol Key enzymes: CYP17A1, CYP21A2, CYP11B1 3.3 Mineralocorticoids: How Aldosterone Is Produced Aldosterone synthesis takes place primarily in the adrenal zona glomerulosa